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Study details
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BARICADE-PRESERVE Trial

Eli Lilly and Company
NCT IDNCT07222332ClinicalTrials.gov data as of Apr 2026
Phase

Phase 3

Target enrollment

300

Study length

about 2.3 years

Ages

1–35

Locations

5 sites in CO, FL, PA +2

About this study

Researchers are testing whether baricitinib can help preserve beta cell function in people newly diagnosed with type 1 diabetes. The trial will last about 60 weeks.

Based on ClinicalTrials.gov records.

What participants do

  • 1.Take Baricitinib
  • 2.Take Placebo
PhasePhase 3
DrugBaricitinib
Routeoral
Primary goalChange from Baseline in C-peptide Area Under the Curve (AUC)

Participation effort

Estimated from trial records. Details can vary by site.

Time + visits
Low8%
Logistics
Moderate50%

Logistics difficulty varies by site location and availability.

Trial highlights

Treatment details

Auto-extracted from trial records to preview treatments and outcomes.

Drug classes

baricitinib

Drug routes

oral (Oral Tablet)

Endpoints

Primary: Change from Baseline in C-peptide Area Under the Curve (AUC)

Secondary: Change from Baseline in Fasting C-Peptide, Change from Baseline in Height, Change from Baseline in Hemoglobin A1c (HbA1c), Change from Baseline in Matsuda Index, Change from Baseline in Mean Total Daily Insulin Dose, Change from Baseline in Number of Manual Insulin Boluses, Change from Baseline in Short Form 36 Version 2 Health Survey, Acute (SF-36v2), Pharmacokinetics (PK): Maximum Concentration (Cmax) of Baricitinib

Body systems

Endocrinology