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Study details
Enrolling now

Methylphenidate to Address Attention and Executive Deficits Among Children With Sickle Cell Disease

St. Jude Children's Research Hospital
NCT IDNCT07226219ClinicalTrials.gov data as of Apr 2026
Phase

Phase 1

Target enrollment

72

Study length

about 2.8 years

Ages

8–17

Locations

1 site in TN

About this study

Researchers are testing if a daily medication called Methylphenidate can help children with sickle cell disease improve their attention, thinking skills, and schoolwork. The trial will also look at any side effects of the medication and how parents make decisions about whether or not to use it.

Based on ClinicalTrials.gov records.

What participants do

  • 1.Take Extended-Release Methylphenidate
PhasePhase 1
DrugExtended-Release Methylphenidate
Routeoral

Participation effort

Estimated from trial records. Details can vary by site.

Time + visits
Low9%
Logistics
Moderate50%

Logistics difficulty varies by site location and availability.

Trial highlights

Treatment details

Auto-extracted from trial records to preview treatments and outcomes.

Drug classes

methylphenidate (CNS stimulant; blocks reuptake of dopamine and norepinephrine)

Drug routes

oral (Disintegrating Oral Tablet)

Endpoints

Secondary: Pediatric Quality of Life Inventory (PedsQL) Multidimensional Fatigue modules, Parent Report, Pediatric Quality of Life Inventory (PedsQL) Sickle Cell Disease modules, Parent Report

Body systems

Psychiatry / Mental Health