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Study details
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A Study of Amivantamab and Olomorasib Combination Therapy

Janssen Research & Development, LLC
NCT IDNCT07227025ClinicalTrials.gov data as of Apr 2026
Phase

Phase 1/2

Target enrollment

60

Study length

about 2.9 years

Ages

18+

Locations

6 sites in CA, NY, PA +3

About this study

This trial is testing the best dose of amivantamab and olomarasib, a combination treatment, for people with metastatic non-small cell lung cancer. The goal is to see how well this combination slows down or stops tumor growth.

Based on ClinicalTrials.gov records.

What participants do

  • 1.Take Amivantamab
  • 2.Take Olomorasib
PhasePhase 1/Phase 2
DrugAmivantamab
Primary goalPhase 1: Number of Participants with Adverse Events (AEs) by Severity

Participation effort

Estimated from trial records. Details can vary by site.

Time + visits
Low15%
Logistics
Moderate50%

Logistics difficulty varies by site location and availability.

Trial highlights

Treatment details

Auto-extracted from trial records to preview treatments and outcomes.

Drug classes

amivantamab

Endpoints

Primary: Phase 1: Number of Participants with Adverse Events (AEs) by Severity, Phase 2: Confirmed Objective Response Rate (ORR)

Secondary: Number of Participants with Adverse Events (AEs) by Severity, Phase 2: Disease Control Rate (DCR), Phase 2: Duration of Response (DoR), Phase 2: Overall Survival (OS), Phase 2: Progression-Free Survival (PFS)

Body systems

Oncology