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Study details
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A Study to Evaluate the Efficacy and Safety of mRNA-1283 and mRNA-1273 in Participants 50 to 64 Years of Age Without High-Risk Conditions for Severe Coronavirus Disease 2019 (COVID-19)

ModernaTX, Inc.
NCT IDNCT07266558ClinicalTrials.gov data as of Apr 2026
Phase

Phase 4

Target enrollment

30,000

Study length

about 1.6 years

Ages

50–64

Locations

150 sites in AL, AZ, CA +35

About this study

Researchers are testing a treatment, mRNA-1273 and mRNA-1283, in adults aged 50 to 64 who do not have high risk factors for severe COVID-19. The trial will last about 567 days and aims to see if the treatments are effective and safe.

Based on ClinicalTrials.gov records.

What participants do

  • 1.Receive Placebo
  • 2.Receive mRNA-1273
  • 3.Receive mRNA-1283
PhasePhase 4
Primary goalNumber of Participants with Serious AEs (SAEs), Medically Attended AEs (MAAEs), AEs of Special Interest (AESIs), and AEs Leading to Discontinuation

Participation effort

Estimated from trial records. Details can vary by site.

Time + visits
Low8%
Logistics
Moderate50%

Logistics difficulty varies by site location and availability.

Trial highlights

Treatment details

Auto-extracted from trial records to preview treatments and outcomes.

Endpoints

Primary: Number of Participants with Serious AEs (SAEs), Medically Attended AEs (MAAEs), AEs of Special Interest (AESIs), and AEs Leading to Discontinuation, Number of Participants with Unsolicited Adverse Events (AEs)

Body systems

Infectious