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Study details
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Dose Escalation Study Evaluating the Safety and Pharmacokinetics of VX-581 in Healthy Participants

Vertex Pharmaceuticals Incorporated
NCT IDNCT07283770ClinicalTrials.gov data as of Apr 2026
Phase

Phase 1

Target enrollment

128

Study length

about 12 months

Ages

18–55

Locations

1 site in KS

About this study

Researchers are testing a treatment called VX-581 to see if it's safe and how it works in healthy people. The trial will last for 345 days, with participants receiving either a placebo or VX-581.

Based on ClinicalTrials.gov records.

What participants do

  • 1.Take Placebo
  • 2.Take VX-581
PhasePhase 1
Primary goalPart A: Safety and Tolerability as Assessed by Number of Participants With Adverse Events (AEs) and Serious Adverse Events (SAEs)

Participation effort

Estimated from trial records. Details can vary by site.

Time + visits
Low9%
Logistics
Moderate50%

Logistics difficulty varies by site location and availability.

Trial highlights

Treatment details

Auto-extracted from trial records to preview treatments and outcomes.

Endpoints

Primary: Part A: Safety and Tolerability as Assessed by Number of Participants With Adverse Events (AEs) and Serious Adverse Events (SAEs), Part B: Safety and Tolerability as Assessed by Number of Participants With Adverse Events (AEs) and Serious Adverse Events (SAEs)

Secondary: Part A: Maximum Observed Plasma Concentration (Cmax) of VX-581, Part B: Maximum Observed Plasma Concentration (Cmax) of VX-581

Body systems

Respiratory