Ketamine and Propofol NeuroImaging Trial
EARLY_PHASE1
60
about 2.4 years
18–59
1 site in PA
About this study
This trial is testing how ketamine and propofol affect brain activity using MRI and EEG scans. The goal is to understand changes in brain connectivity related to memory formation and pain perception during anesthesia.
Based on ClinicalTrials.gov records.
What participants do
- 1.Take Ketamine
- 2.Take Propofol
- 3.Use Peripheral Nerve Stimulation
Participation effort
Estimated from trial records. Details can vary by site.
Logistics difficulty varies by site location and availability.
Trial highlights
Treatment details
Auto-extracted from trial records to preview treatments and outcomes.
ketamine (NMDA receptor antagonist; induces dissociative anesthesia and analgesia), propofol (Facilitates GABA; induces unconsciousness)
injection (Injection)
Primary: Pain intensity and unpleasantness ratings, comparing single-drug to drug-combination condition
Secondary: MRI-based activation during memory formation, comparing the single-drug condition to the combination-drug condition, MRI-based activation during painful stimulation, comparing the single-drug condition to the combination-drug condition, MRI-based changes in functional connectivity, comparing the single-drug condition to the combination-drug condition
therapeutic