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Study details
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Open-label Study to Evaluate Brain α-Synuclein Deposition Using PET and [18F]MK-0947 in Parkinson's Disease

Invicro
NCT IDNCT07348250ClinicalTrials.gov data as of Apr 2026
Phase

EARLY_PHASE1

Target enrollment

22

Study length

about 1.1 years

Ages

18–80

Locations

1 site in CT

About this study

This trial is testing a new imaging drug called [18F]MK-0947 to see if it can help doctors visualize changes in the brain related to Parkinson's disease (PD). The drug works with PET scans to show areas of the brain where α-synuclein builds up, which is linked to PD. The trial aims to determine if [18F]MK-0947 is safe and effective for visualizing α-synuclein in the brain.

Based on ClinicalTrials.gov records.

What participants do

  • 1.Take [18F]MK-0947
PhaseEARLY_Phase 1
Primary goalSafety of [18F]MK-0947: Incidence of Adverse Events

Participation effort

Estimated from trial records. Details can vary by site.

Time + visits
Low10%
Logistics
Moderate50%

Logistics difficulty varies by site location and availability.

Trial highlights

Treatment details

Auto-extracted from trial records to preview treatments and outcomes.

Endpoints

Primary: Safety of [18F]MK-0947: Incidence of Adverse Events

Secondary: Model-derived Pharmacokinetics of [18F]MK-0947

Body systems

Neurology