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Study details
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A Study of Brenipatide in Adult Participants With Schizophrenia

Eli Lilly and Company
NCT IDNCT07410507ClinicalTrials.gov data as of Apr 2026
Phase

Phase 2

Ages

18–55

Locations

31 sites in AR, CA, CT +12

About this study

This Phase 2 study is focused on people with schizophrenia. The primary outcome being measured is Percent Change from Baseline in Body Weight in Participants with a Baseline Body Mass Index ≥25.0 Kilograms per Meter Squared (kg/m²).

Based on ClinicalTrials.gov records.

PhasePhase 2
Primary goalPercent Change from Baseline in Body Weight in Participants with a Baseline Body Mass Index ≥25.0 Kilograms per Meter Squared (kg/m²)

Participation effort

Estimated from trial records. Details can vary by site.

Time + visits
Low5%
Logistics
Moderate50%

Logistics difficulty varies by site location and availability.

Trial highlights

Treatment details

Auto-extracted from trial records to preview treatments and outcomes.

Endpoints

Primary: Percent Change from Baseline in Body Weight in Participants with a Baseline Body Mass Index ≥25.0 Kilograms per Meter Squared (kg/m²)

Secondary: Change from Baseline in Clinical Global Impression - Severity - Schizophrenia (CGI-S-SCH), Change from Baseline in Patient Global Impression - Severity, Change from Baseline in Positive and Negative Syndrome Scale (PANSS) Total Score, Change from Baseline on Neurocognitive Battery Composite Test Score at Week 36, Change from Baseline on the Schizophrenia Cognition Rating Scale (SCoRS) Total Score, Change from Baseline on the Virtual Reality Functional Capacity Assessment Tool (VRFCAT) Total Completion Time, Percentage of Participants with Body Mass Index ≥25 kg/m2 (BMI) Who Achieve Body Weight Reduction of ≥5%, Pharmacokinetic (PK): Average Steady State Plasma Concentration (Cavg) of Brenipatide

Body systems

Psychiatry / Mental Health